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Improved characterization of chronic wounds in RDEB

Project lead Prof John McGrath
Organisation King’s College London, London, UK
Partner organizations & collaborators Co-Researchers: Dr Ciro Chiappini, Dr Mads Bergholt, Prof Jemima Mellerio
Collaborator: Mölnlycke Health Care
Project budget GBP 142,035.00
Start date / Duration 01. Sep 2022 / 30 months
Funder(s) / Co-Funder(s) DEBRA UK
Research area Symptom prevention & relief

Project details

Short lay summary

This project offers a new approach to assessing wounds and wound healing interventions in the inherited blistering skin disease, recessive dystrophic epidermolysis bullosa (RDEB).

Ultimately, we wish to develop a bedside test to inform on whether a wound is healing or not, whether a biopsy is indicated (e.g., for cancer), or what might be the best dressing to apply to the wound to promote optimal wound healing.

Learn more on DEBRA UK's website.

Strategic relevance

Our project hopes to develop a new bedside tool which can use painless nanoneedle sampling to generate nanobiopsy material which can then be evaluated to generate data which give a better indication of whether SCC is present and whether a skin biopsy is needed or not. Thus, developing a bedside diagnostic tool will improve how EB healthcare teams evaluate and monitor wounds in people with RDEB.
The second goal is to be able to generate molecular data about wounds and how these are impacted by the application of certain dressings… Ultimately, we hope to be able to use this information to help EB healthcare teams and people with EB choose and apply the best dressings to help their wounds heal.

John McGrath


chronic wounds
McGrath 22
St. John's Institute of Dermatology
King's College
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